The show is set in the human world and focuses on a young girl named Leah who is friends with a pair of twin genie sisters named Shimmer and Shine. Each day, the genies grant Leah three wishes, but they often make mistakes. Each episode features Leah working together with the genies to resolve the problems they unintentionally cause, all while keeping Shimmer and Shine a secret from her next door neighbor and best friend Zac.